I've been a huge fan of GURPS since I was introduced to it back in '97 with 3rd edition. I have several of the books but have never played it. (Don't you hate having books and never getting to use them? ) Though even without using the system I've been able to use the books as reference materials elsewhere so not a total loss.
All in all I'd love to find a game using GURPS because it pretty much lets you run anything, it's all up to the GM to "Trim the Fat" as it were to let newer players in. Maybe give them condensed options to chose from. ;