Is it me or do some of the 4e rules for D&D strike a familiar cord? The formula for caster's spells in particular strike me as stemming from a generic power system with the focus being a generic approach to D&D. It's like they took and removed the technical framework after they constructed the powers with the Hero system (not specifically Hero, but something similar in method).
It also looks as though simple game elements can be added to the system to make it generic. The mechanics are there, just add interactive elements.
Such as adding Damage Type: Cyber
or Effect Type: Biotic
Poof! Instant shadowrun a la d&d.
Then again, I don't have the rules yet. So, I'm just speculating.