I usually just send the players to a wacky place where all the good guys are now evil with facial hair. If they don't want to play Star Trek, I guess it's time to start rolling those new characters.
Check out this new article Wizards of the Coast posted recently:
Dungeon Side Trek: Teleport Gone Awry
Ever been at a loss for what to do when a PC teleports and rolls "similar area" on that pesky table? Well here's a solution, ready to run in this Side Trek.