Calling-in-Sick?

**GoddessGood** · 12-15-2008, 03:38 PM

The one on the far left, nicknamed Kate Mouse. It's too thin to see in this shot, though.

**Dark** · 12-18-2008, 04:58 PM

Hell I still call in sick sometimes and I'm 40!

**GoddessGood** · 12-19-2008, 08:57 AM

I wish I could have called in sick

Not enough paid time off for that.

**Total Nerd v2.135 (final)** · 12-20-2008, 12:03 PM

Back in the 1950s, businesses were insanely lenient about sick leave and vacation time. I guess they weren't competing with the emerging economies, just the USSR.

and adjusted income, relative to today, was insanely high in the 1950s

**Moritz** · 01-05-2009, 08:39 AM

This is neither a case overeating or exercise. This is a 'genetic' experiment.

The mouse on the left is Leptin deficient. Leptin is a protein produced by fat cells under direction of the ob gene that decreases appetite and increases energy expenditure - sometimes called the ob protein.

Therefore, the experiment ran on these mice displays the turning off of the ob gene in both mice. The one on the right received leptin injections and remained a regular weight. The one on the left did not, therefore became obese.

So yes, this is a genetic disposition and yes, genetics can cause weight issues.

Understand, we should live in a reality based community, one based on observations - not on faith, assumptions, or ideals. So don't go assuming that just because someone is fat they're lazy or gluttonous.

Originally Posted by Total Nerd v2.135 (final)

Im sure. not that I would know anything about genetics lol.

clearly, one of these mice is just terribly lazy and gluttonous, im sure!
guess which one was starved it's whole life?

**Total Nerd v2.135 (final)** · 01-07-2009, 01:13 AM

Originally Posted by Moritz

This is neither a case overeating or exercise. This is a 'genetic' experiment.

The mouse on the left is Leptin deficient. Leptin is a protein produced by fat cells under direction of the ob gene that decreases appetite and increases energy expenditure - sometimes called the ob protein.

Therefore, the experiment ran on these mice displays the turning off of the ob gene in both mice. The one on the right received leptin injections and remained a regular weight. The one on the left did not, therefore became obese.

So yes, this is a genetic disposition and yes, genetics can cause weight issues.

Understand, we should live in a reality based community, one based on observations - not on faith, assumptions, or ideals. So don't go assuming that just because someone is fat they're lazy or gluttonous.

Thank you! Moritz!

I am glad to see you are familiar with the experiment. the gene was actually ligated out with cDNA in the mouse embryos, so the gene was 'knocked out' and not so much turned off (harder to do and involves siRNAs or other hormones)
I am not sure if it was the leptin gene they knocked out or the ghrelin / obistatin / pre-proghrelin gene

there are actually many hormones (some being peptides like leptin and ghrelin), with numerous origins, that influence the hypothalamic, mesolimbic, and nucleus accumbens mediated energy expenditure and intake of the whole organism.
Most dysregulation of energy homeostasis not caused by SNPs in relevant genes are caused by external stressor, which are common enough.

I am always so pissed off at the way the media and so called 'Health Care' community demonize, criticize, and mock overweight or obese people and act like it is the most terrible thing. Its like like they want people to worry more about their weight than smoking or STDs.

But one sad thing to realize is that the world will always be superficial like this and that popular opinions and understanding will not change very much, regardless of how it changes or develops in the academic community.

**Goreaddict** · 04-01-2009, 09:37 PM

called in sick to play d&d with a huge group

was when i first started playing and it was epic. Other than that i missed an entire week of school for Halo 3 and Gears of war 2 >.< me and a bunch just laid out doesn't hurt me straight a's (b in prob and stats >.> )

**Rook** · 05-24-2009, 09:58 PM

We all occasionally need a mental health day. I didn't take one this year, but it's probably the first year that I haven't done so in the last decade.

**tesral** · 05-25-2009, 06:15 AM

Zombie thread!!

**Panthro82** · 05-25-2009, 07:30 AM

mental health is exactly how I look at it. and I have almost never felt bad calling in. I look at it like if I don't do it occasionally, the constant day in and day out routine of working will drag my energy down, which will effect my performance. Like steering a ship and being off by 1 degree. Being off by 1 degree means nothing in the short run. Over a long period of time however, you wind up waaay off course. I look at it like they should be thanking me that I decided 15 minutes before I was supposed to leave my house for work, that I instead decided to sit down and play video games most of the day. Or taking the day off to have a LOTR marathon(all 3 in a row)

In the long run I will be more productive for having missed that day to indulge. I used to do this often at my old job, because they treated me like crap and the job sucked. I didn't do it once at my last job because they were nazi's and if you missed 1 day within the first 3 years of working there without it being death in the family or being hospitalized, you would be fired.

**GoddessGood** · 05-26-2009, 07:27 AM

Taking a day off wouldn't have done me much good this past weekend. Both games got canceled

It'll be a month and a half between my last game and my next one, which is totally uncool because I'm in two group with no overlap. I'll go over in the corner and pout some more

**WhiteTiger** · 08-11-2009, 03:13 PM

I have called in sick because we stayed up too late trying to finish an adventure or campaign... it happens.

**Arch Lich Thoth-Amon** · 08-11-2009, 03:15 PM

Originally Posted by Rook

We all occasionally need a mental health day. I didn't take one this year, but it's probably the first year that I haven't done so in the last decade.

Originally Posted by Panthro82

mental health is exactly how I look at it. and I have almost never felt bad calling in. I look at it like if I don't do it occasionally, the constant day in and day out routine of working will drag my energy down, which will effect my performance. Like steering a ship and being off by 1 degree. Being off by 1 degree means nothing in the short run. Over a long period of time however, you wind up waaay off course. I look at it like they should be thanking me that I decided 15 minutes before I was supposed to leave my house for work, that I instead decided to sit down and play video games most of the day. Or taking the day off to have a LOTR marathon(all 3 in a row)

In the long run I will be more productive for having missed that day to indulge. I used to do this often at my old job, because they treated me like crap and the job sucked. I didn't do it once at my last job because they were nazi's and if you missed 1 day within the first 3 years of working there without it being death in the family or being hospitalized, you would be fired.

You both nailed it. It definitely is a mental health day.

**Scott** · 08-13-2009, 11:40 AM

Sure, I've "called in sick" when in reality I could have gone in. I've done it a few times when there was a event like going to a movie or a renaissance fair... but, I don't think I've ever called in because of a RPG -either playing one or recovering from a late night session...