I am putting together a campaign set in the Seattle area after a worldwide plague. It draws its inspiration from lots of sources, so if you are familiar with Fallout, Fallen Earth or the television show Revolution you will be right on track. It's not about the fall of civilization, but what comes after.
Don't worry about the game system. You don't need to know it, and you don't need to own the books.
Details can be found on Obsidian Portal.