I have run it before and it went well, at least as far as the system goes. The players were more into combat oriented games so the change to finesse oriented did not go over well with all of them. The system, as I said, holds it own. Ive also played LUG's Star Trek TNG game and like that as well. The hardest part about these games is the system looks intimidating, but really isn't once you get used to it. Since I played Star Trek before DUNE, I was familiar with the system and things ran smooth. So if your players are into the setting and if they take the time to get familiar with the system, you should have no problems at all.