I find that I have to mold the game for the players. Although I prefer the Fasa MW 2nd as a frame (2d6-simple, streamlined, low math system) I once re-valued the system for the 3d6 dice. It worked well enough that I would do it again if I had to.

The story arc is wide and deep. Swim. Enjoy. Do what makes you (and your players) happy.