You could have descendants of humanity that may have mutated into crazies from the virus/starvation/life in general, etc.
These PC's could struggle to survive, or they could bunker down, secure an area and start a "plantation."
Generally though, there should be other humans in the storyline. Having just 4-6 people in an entire highly evolved world isn't cool; however, whether the other humans are good or bad could be completely up to you.




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