Not a big deal to me. If they cant meet salary demands (i'm sure they can, but that's a topic for another time), then i have no problem with them replacing the actors, their voices, specifically.
In the end, i will remain a Futurama fan. But i will admit to this, if they dont hire some new writer blood, i may not be a fan for much longer. As of right now, it seems kinda dry and unimagined.