IIRC, an early version of GURPS depicted vampires as immune to inert materials like metal, but vulnerable to once-living materials like wood. (Or the fist of a Slayer, maybe?)
Another weird one comes from Shadowrun, the graphic novel Midnight Nation and an indie game called UnChosen: a specific aspect of reality, or reality in general, rejects the character's existence. Yes, you're impervious to wood, but you also can't pick up or move anything wooden. Or, people ignore your existence even if you shout at them; you can go where you want and steal what you want -- if reality will let you take it -- but no one will help you if you're in trouble, or listen to your warnings, or speak to you, ever.
If I'm forced to be original, how about knowing exactly what time it is, anywhere in the world, no matter where you are or what happens to you. Sure, you never need a watch, and other people synchronize their watches with you; a creative person can figure out more interesting uses, a la the animated Clock King. Still, other superheroes and supervillains will laugh at you.
"On two occasions I have been asked [by members of Parliament], 'Pray, Mr. Babbage, if you put into the machine wrong figures, will the right answers come out?' I am not able rightly to apprehend the kind of confusion of ideas that could provoke such a question."
- Charles Babbage (1791 - 1871)
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