I'm looking for a game that has a lot of inter-character interaction, ongoing storylines, just enough combat to keep the story flowing, and the minimum accounting necessary to manage the characters. Games that are little more than exercises in bookkeeping, or that posit that the PCs are all doomed and the only thing that matters is how "cool" you are as you go to Hell, are both major turn-offs.
I've been playing D&D since the gray box, stopped playing it when 2e came out, have very little experience with 3e, played the Atlantean World game for several years (started when Bard Games was the publisher, continued playing after Wizards bought it from Bard), have played Champions and Gurps, played White Wolf games for long enough to decide I will NEVER play White Wolf (or similar) games again, and GMed Shadowrun from the time when 1st ed. was only available in hardcover right up until FASA self-destructed and Shadowrun was no longer readily available. I haven't played a tabletop game in almost 10 years, but would really like to get back into it, if I can find a gaming group that's close enough to where I live that I can afford the cost of gas to meet up with the group.